Bhandari Lab Publications





Das P, Acharya S, Prahaladan VM, Kumova OK, Malaeb S, Behera S, Agarwal B, Christensen DJ, Carey AJ, Bhandari V. Chitin-Derived AVR-48 Prevents Experimental Bronchopulmonary Dysplasia (BPD) and BPD-Associated Pulmonary Hypertension in Newborn Mice. Int J Mol Sci. 2021 Aug 9;22(16):8547. doi: 10.3390/ijms22168547. PMID: 34445253

Das P, Shah D, Bhandari V.miR34a: a novel small molecule regulator with a big role in bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L228-L235. doi: 10.1152/ajplung.00279.2020. Epub 2021 Apr 7. PMID: 33825492

Shah D*, Das P*, Acharya S, Agarwal B, Christensen DJ, Robertson SM, Bhandari V. Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). Int J Mol Sci. 2021 Mar 4;22(5):2573. doi: 10.3390/ijms22052573. PMID: 33806560 * Equal first author

Das P, Curstedt T, Agarwal B, Prahaladan VM, Ramirez J, Bhandari S, Syed MA, Salomone F, Casiraghi C, Pelizzi N, Bhandari V. Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits. Front Physiol. 2020 Apr 9;11:266. eCollection 2020. PMID: 32327998

Gilfillan M, Das P, Shah D, Alam MA, Bhandari V. Inhibition of microRNA-451 is associated with increased expression of Macrophage Migration Inhibitory Factor and mitgation of the cardio-pulmonary phenotype in a murine model of Bronchopulmonary Dysplasia. Respir Res. 2020 Apr 22;21(1):92. doi: 10.1186/s12931-020-01353-9. PMID: 32321512

Chaubey S, Nader YM, Shah D, Kumova OK, Prahaladan V, Carey AJ, Andersson S, Bhandari V.α1,3-Fucosyltransferase-IX, an enzyme of pulmonary endogenous lung stem cell marker SSEA-1, alleviates experimental bronchopulmonary dysplasia. Pediatr Res. 2020 Apr 17. doi: 10.1038/s41390-020-0891-9. PMID: 32303051

Shah D, Torres C, Bhandari V. Adiponectin deficiency induces mitochondrial dysfunction and promotes endothelial activation and pulmonary vascular injury.FASEB J. 2019 Dec;33(12):13617-13631. doi: 10.1096/fj.201901123R. Epub 2019 Oct 4. PMID: 31585050

Das P, Panda SK, Agarwal B, Behera S, Ali SM, Pulse ME, Solomkin JS, Opal SM, Bhandari V, Acharya S. Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. Sci Rep. 2019 Feb 27;9(1):2904. doi: 10.1038/s41598-019-38731-3. PMID: 30814582

Leary S, Das P, Ponnalagu D, Singh H, Bhandari V. Genetic Strain and Sex Differences in a Hyperoxia-Induced Mouse Model of Varying Severity of Bronchopulmonary Dysplasia. Am J Pathol. 2019 May;189(5):999-1014. doi: 10.1016/j.ajpath.2019.01.014. Epub 2019 Feb 19. PMID: 30794808

Alam MA, Betal SGN, Aghai ZH, Bhandari V.Hyperoxia causes miR199a-5p-mediated injury in the developing lung. Pediatr Res. 2019 Nov;86(5):579-588. doi: 10.1038/s41390-019-0524-3. Epub 2019 Aug 8. PMID: 31390652

Chaubey S, Thueson S, Ponnalagu D, Alam MA, Gheorghe CP, Aghai Z, Singh H, Bhandari V. Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6.Stem Cell Res Ther. 2018 Jun 26;9(1):173. doi: 10.1186/s13287-018-0903-4. PMID: 29941022

Lal CV, Olave N, Travers C, Rezonzew G, Dolma K, Simpson A, Halloran B, Aghai Z, Das P, Sharma N, Xu X, Genschmer K, Russell D, Szul T, Yi N, Blalock JE, Gaggar A, Bhandari V, Ambalavanan N.Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants.JCI Insight. 2018 Mar 8;3(5). pii: 93994. doi: 10.1172/jci.insight.93994. PMID: 29515035

Das P, Syed MA, Shah D, Bhandari V.miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia. Cell Stress. 2018 Jan 9;2(2):34-36. doi: 10.15698/cst2018.02.1224. PMID: 31225464

Syed M, Das P, Pawar A, Aghai ZH, Kaskinen A, Zhuang ZW, Ambalavanan N, Pryhuber G, Andersson S, Bhandari V. Nat Commun. 2017 Oct 27;8(1):1173. doi: 10.1038/s41467-017-01349-y.Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs. PMID: 29079808

Sureshbabu A, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V.Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice.Am J Respir Cell Mol Biol. 2016 Nov;55(5):722-735. PMID: 27374190

Syed MA, Choo-Wing R, Homer RJ, Bhandari V.Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs.PLoS One. 2016 Jan 22;11(1):e0147588. doi: 10.1371/journal.pone.0147588. eCollection 2016. PMID: 26799210

Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ. An Analysis of MIF Structural Features that Control Functional Activation of CD74.Chem Biol. 2015 Sep 17;22(9):1197-205. doi: 10.1016/j.chembiol.2015.08.006. Epub 2015 Sep 10. PMID: 26364929

Sureshbabu A, Syed MA, Boddupalli CS, Dhodapkar MV, Homer RJ, Minoo P, Bhandari V. Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung. Respir Res. 2015 Jan 16;16:4. doi: 10.1186/s12931-014-0162-6. PMID: 25591994

Berger J, Bhandari V.Animal models of bronchopulmonary dysplasia. The term mouse models. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 15;307(12):L936-47. doi: 10.1152/ajplung.00159.2014. Epub 2014 Oct 10. Review. PMID: 25305249

Sureshbabu A, Bhandari V. Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy. Front Physiol. 2013 Dec 26;4:384. doi: 10.3389/fphys.2013.00384. Review. PMID: 24421769

Syed MA, Bhandari V. Hyperoxia exacerbates postnatal inflammation-induced lung injury in neonatal BRP-39 null mutant mice promoting the M1 macrophage phenotype. Mediators Inflamm. 2013;2013:457189. doi: 10.1155/2013/457189. Epub 2013 Nov 17. PMID: 24347826

Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ. MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10994-9. doi: 10.1073/pnas.1221817110. Epub 2013 Jun 17. PMID: 23776208

Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PLoS One. 2013 Apr 29;8(4):e60560. doi: 10.1371/journal.pone.0060560. Print 2013. PMID: 23637753

Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V. Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. Am J Respir Cell Mol Biol. 2013 Jun;48(6):749-57. doi: 10.1165/rcmb.2012-0381OC. PMID: 23470621

Sun H, Choo-Wing R, Fan J, Leng L, Syed MA, Hare AA, Jorgensen WL, Bucala R, Bhandari V. Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia. Respir Res. 2013 Feb 28;14:27. doi: 10.1186/1465-9921-14-27. PMID: 23448134

Ghelfi E, Yu CW, Elmasri H, Terwelp M, Lee CG, Bhandari V, Comhair SA, Erzurum SC, Hotamisligil GS, Elias JA, Cataltepe S. Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. Am J Pathol. 2013 Apr;182(4):1425-33. doi: 10.1016/j.ajpath.2012.12.009. Epub 2013 Feb 4. PMID: 23391391

Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA. Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2.Am J Respir Cell Mol Biol. 2012 May;46(5):668-76. doi: 10.1165/rcmb.2011-0074OC. Epub 2012 Jan 6.
PMID: 22227562

Li Z, Choo-Wing R, Sun H, Sureshbabu A, Sakurai R, Rehan VK, Bhandari V. A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung. BMC Cell Biol. 2011 Dec 15;12:54. doi: 10.1186/1471-2121-12-54. PMID: 22172122

Harijith A, Choo-Wing R, Cataltepe S, Yasumatsu R, Aghai ZH, Janér J, Andersson S, Homer RJ, Bhandari V. A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2011 May;44(5):621-30. doi: 10.1165/rcmb.2010-0058OC. Epub 2011 Jan 7. PMID: 21216975

Bhandari A, Bhandari V. Pitfalls, problems, and progress in bronchopulmonary dysplasia. Pediatrics. 2009 Jun;123(6):1562-73. doi: 10.1542/peds.2008-1962. Review. PMID: 19482769

Bhandari V. Molecular mechanisms of hyperoxia-induced acute lung injury. Front Biosci. 2008 May 1;13:6653-61. Review. PMID: 18508685

Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ, Elias JA. Developmental regulation of NO-mediated VEGF-induced effects in the lung. Am J Respir Cell Mol Biol. 2008 Oct;39(4):420-30. doi: 10.1165/rcmb.2007-0024OC. Epub 2008 Apr 25. PMID: 18441284

Bhandari V, Elias JA.The role of angiopoietin 2 in hyperoxia-induced acute lung injury.Cell Cycle. 2007 May 2;6(9):1049-52. Epub 2007 May 2. Review. PMID: 17438375

Bhandari V, Choo-Wing R, Homer RJ, Elias JA. Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice.J Immunol. 2007 Apr 15;178(8):4993-5000. PMID: 17404281

Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V. Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L142-50. Epub 2007 Mar 30. PMID: 17400600

Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov;12(11):1286-93. Epub 2006 Nov 5. PMID: 17086189